Improving interpretation for antiviral drug resistance

antiviral drug resistance interpretation

HIV-1

Interpretation of HIV-1 drug resistance is one of the major challenges of antiretroviral therapy (ART) monitoring. A substantial number of interpretation systems is available. HIV-GRADE has been developed in the context of other frequently used interpretation systems including the ANRS algorithm, the Stanford database and geno2pheno. Additionally, extensive databases including data of thousands of genotypes, pairs of genotypic and phenotypic data, therapy response, clinical experience of the participating experts and last but not least results from clinical trials have influenced the algorithm. You can access the HIV-1 tool here.

GRADE is an acronym for Genotypic Resistance-Algorithm DEutschland.

HIV-2

HIV-2 treatment is especially challenging. Treatment options are more limited, experience with drugs that are usually only approved for HIV-1 treatment is more limited. Members of the HIV-GRADE team developed together with other specialist the HIV2EU algorithm and the interpretation tool is hosted on this site.

HBV

Infections with Hepatitis B virus remain a global health problem. Identification of virus strains resistant to current treatment options and strains that show typical mutations for immune-escape is an integral part of managing treatment options. You can access the HBV tool here.